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Individuals with other psychiatric disorders or conditions significantly affecting functioning, behaviour, or life situation (intellectual disability, psychotic disorder, bipolar disorder, autism spectrum disorder, personality disorder, ongoing depression, diagnosed brain lesion, ongoing substance use disorder, or criminality) were not eligible.
Therefore, we hypothesized that cognitive status at baseline and subsequent changes in cognition could predict functioning either directly or indirectly via psychiatric symptoms, but not the other way around (e.g. changes in psychiatric symptoms affecting functioning via changes in cognition).
One of the main areas affecting functioning in individuals with Rett syndrome is a severe impairment of receptive and expressive communication.
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About 4 to 5percentt of adolescents fit the diagnostic criteria for insomnia — the problem is frequent, lasts at least a month and is severe enough to affect functioning.
Response categories were used to measure severity included (1) No difficulties, (2) Difficulties do not affect functioning, (3) Difficulties affect functioning somewhat, (4) Difficulties affect functioning a lot, (5) Difficulties affect functioning very much.
Conclusions: Even highly functioning individuals may have sequelae from prior TBI that can affect functioning.
Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown.
Positive symptoms also affected functioning at baseline although independent of cognition.
RRP did not affect functioning scales of the EORTC QLQ-C30.
In all countries, the participants stated that SSc influenced and affected functioning and health.
In addition, we found that positive symptoms also affected functioning at baseline.
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