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In particular, the triazole analogue 6 (IC50 against hDHODH: 45 nM) exerted potent in vitro antiproliferative and immunosuppressive activity without affecting cell survival.
These results raise the possibility that chronic exposure to low, subanesthetic concentrations of ketamine, while not affecting cell survival, could still impair neuronal morphology and thus might lead to dysfunctions of neural networks.
Quinpirole significantly potentiated ExpHtt-induced neuronal death without affecting cell survival in Htt-expressing neurons.
Second, we focused only on siRNA influencing the up-regulation of CYP1A1 activity in response to TCDD exposure, without concomitantly affecting cell survival and proliferation.
This led us to identify 22 kinases (Table 1) as candidates potentially implicated in up-regulation of EROD activity in response to TCDD, without affecting cell survival and proliferation.
However, through reversible S-nitrosylation of cysteine residues on specific regulatory proteins, NO has the unique function of affecting cell survival and death, mostly reported for endothelial cells and neurons [17], [18].
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Cryopreservation did not affect cell survival.
In addition, this peptide did not affect cell survival measured with the MTT assay.
Mechanical stress is widely known to affect cell survival and extracellular matrix metabolism in many cell types.
Labelling did not affect cell survival of mononuclear cells as measured by the MTS cell survival assay (n = 12, p > 0.05; Fig. 4b).
Bcl11b deletion in mature ILC2 cells does not affect cell survival but results in a loss of ILC2 identity (Califano et al., 2015).
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