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The phrase "affecting a large number" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a significant quantity of people or things.
Example: "The new policy is affecting a large number of employees, leading to widespread changes in the workplace."
Alternatives: "impacting many" or "influencing a significant number".
Exact(30)
If all three spike linearly, there's likely an ISP issue beyond our control affecting a large number of users.
Psoriasis and atopic dermatitis are chronic and relapsing inflammatory diseases of the skin affecting a large number of patients worldwide.
Pandemics are generally defined as epidemics that occur over a wide area, crossing international boundaries and affecting a large number of people.
Improvements in transport infrastructures have a positive impact on regional development and significant repercussions on the economy, as well as affecting a large number of ecological processes.
One egregious rule bars legal services providers from representing clients in class-action lawsuits — even though such suits can be an efficient way to obtain relief for problems affecting a large number of people.
As an illustration, studies about the transcription amplification mediated by the oncogene c-Myc have uncovered that it regulates the promoter-proximal pausing of RNA polymerase II, affecting a large number of genes already activated by other regulatory mechanisms66,67,68.
Similar(30)
Although both factors affected the distribution of mammal species, management intensification had a stronger effect, negatively affecting a larger number of species.
The consultation found social media provided hate-crime perpetrators with a veil of anonymity, making it harder to bring them to justice and potentially affecting a larger number of people.
Does it affect a large number of people or a small number?
Osteoarthritis (OA) is a joint disease that affects a large number of the population nowadays.
Anorexia nervosa (AN) affects a large number of women, usually in their adolescence.
More suggestions(15)
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threatening a large number
engaging a large number
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impacting a large number
reflecting a large number
affecting a broad number
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com