The phrase "affecting a large majority" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a significant portion of a population or group.
Example: "The new policy is affecting a large majority of the employees, leading to widespread changes in workflow."
Alternatives: "impacting a significant number" or "influencing a vast majority."
According to our results, the impairment of cardiac sympathetic innervation during the acute stage of SAH affected a large majority of patients.
We ignore this issue here because, as discussed later on, changes in EPL did not affect on impact a large majority of these workers.
The ratio of collective violence in low- and middle-income countries (LMIC) versus high-income countries (HIC) is 10 to 1. Political violence particularly affects LMIC: a large majority of the 33 armed conflicts recorded in 2013 took place in low-income settings, and generally in Asia (39%%) and Africa (39%%) [ 17].
Asked how the "Arab spring" uprisings might affect Sudan, where Arabic speakers comprise a large majority of the northern population, Bashir said the small protests calling for increased democracy lacked broad support.
And looking at age, 75% of people aged 18-30 reporthatat a person's religious beliefs wouldn't affect their vote--suggesting that soon, a large majority of Americans will support nonreligious candidates for President.
Surprisingly, a large majority of genes affected in knockout were unaffected in overexpression and vice versa, supporting different mechanisms underlying behavioral and cellular defects of these two genetic models.
During carcinogenesis, a large majority of signaling molecules are affected, and their downstream effectors are generally transcription factors.
The rule affects Comcast, CenturyLink and local ISP Wave; these three account for a large majority of broadband subscribers in the city.
Most people (but not such a large majority) also think that something else is impossible, namely affecting what happened in the past or causing something to have happened in the past.
Results: A large majority of respondents agreed that climate change would affect vector-borne (86% of country representatives), food-borne (70%), water-borne (68%), and rodent-borne (68%) diseases in their countries.
