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In the present study, we used a genetic approach to specifically eliminate myostatin activity after normal development, and we examined how this affected weight gain, muscle mass, fat mass, glucose levels and hepatic steatosis after a prolonged period of high-fat feeding.
Dietary protein levels significantly affected weight gain but within a protein level, higher lipid levels resulted in reduced growth.
However, lipid significantly (P < 0.05) affected weight gain with fish fed the diet containing 18% total lipid returning the lowest growth of 293%.
Exclusive breast feeding till 6 months adversely affected weight gain, but it was not statistically significant (p=0.06; see online supplementary table S3b).
This suggests that, in particular, the high-fat group had lower compliance at this time point, which affected weight gain in the total LCD-cohort (i.e. −3.5 ± 4.0 kg in completers compared with −2.3 ± 5.1 kg in the total cohort).
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The dysentery-affected animals had a daily weight gain per kg of 24 ± 1 g kg-1 prior to the clinical signs of disease.
In the 1980's, an Australian postal survey recorded that 81% of cattle owners reported the occurrence of IBK in their herds and 75% observed a reduction in weight gain of the affected cattle [ 9].
Even though maternal smoking in pregnancy may result in growth restriction in utero, some studies have found that affected infants exhibit extremely high rapid postnatal weight gain.
These results are consistent with several studies which observed SGA metabolic side-effects even in patients without any weight gain [ 30] and affected by mood disorders [ 31].
Most affected were children who experienced compensatory "catch-up growth" or accelerated weight gain in childhood.
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