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The value λ of was an adjustable parameter that affected the specificity of each model.
The prevalence of diseases in the aseptic group could have hypothetically affected the specificity of our results.
Firstly, we limited the list of positive and negative words, and the choice of words was likely to have affected the specificity of the observed patterns.
In particular, it has been documented that indel errors occurring in homopolymer DNA regions have significantly affected the specificity of indel detection [ 3, 6, 11, 12].
Mutation of K350 to alanine significantly affected the specificity of GlaB binding, as the small molecule was no more able to interact within ZF4 and ZF5 (Fig 3B).
In our study, higher tumour M2 PK levels were observed in older age groups than in younger age groups, which slightly affected the specificity of the test but not its sensitivity.
Similar(52)
Although the ECD of HER2 contains several potential N-linked glycosylation sites, studies of its glycoforms have been limited to an examination of how HER2 glycosylation affected the specificities of a panel of anti-HER2 antibodies [ 88].
The number of profiles available for a cancer type may affect the specificity of certain metabolic requirements (for PC, only two profiles of exchange fluxes were available), therefore biasing the quality of the in silico predictions when these are enforced as constraints in FBA.
The conformation and lipidation status of apoE may affect the specificity of its receptor binding.
More dramatically, these same agents enhanced the affinity of the receptor by ten-fold, without affecting the specificity of the receptor.
Third, false positives could be due to the cross-hybridization of paralogous gene targets to individual probes, which may affect the specificity of the SFP calling.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com