Exact(16)
One commonly affected pathway was the Neuroactive Ligand-Receptor Interaction pathway.
Accordingly, LPS/IL-1 mediated inhibition of the retinoid X receptor (RXR) function and liver X receptor (LXR)/RXR activation was found to be the most significantly affected pathway after 48 hours of LPS stimulation (Figure 1).
"√" means significantly affected pathway.
Another affected pathway involved genes related to the glutathione homeostasis.
NOTCH signaling pathway is the most frequently affected pathway in HNC.
Ribosomal-associated proteins constituted the only significantly affected pathway for the upregulated DEGs (Q <0.05).
Similar(44)
An integrated analysis was used to clarify the relationship between the major active components, the affected targets and affected pathways.
Affected pathways included retinoid signaling and metabolism, cell-cycle regulation, lineage determination, cell adhesion, cell-matrix interaction and cytoskeleton remodeling.
The genes, exhibiting ≥2-fold change in expression with the false discover rate (FDR) ≤0.01, were considered as 'differentially expressed' and further examined to identify affected pathways.
Gene ontology and KEGG pathway analyses were performed in GeneSifter to identify affected pathways.
Most significantly affected pathways included those involved in Cell adhesion and Cytokine-cytokine receptor interaction.
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