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In the most severely affected neurons, vacuoles filled the soma and neuronal processes (Fig. 6E).
For potential RTT gene therapy, MeCP2 must be expressed in affected neurons and their supporting glial cells.
Addionally, recruitment or trapping of U2AF65 in the single large nuclear aggregates of SCA1 affected neurons could have a detrimental effect on splicing.
Affected neurons accumulate iron leading to a coarse intracellular appearance that recedes in degenerating cells.
(108) In affected neurons, ubiquitin accumulates in inclusion bodies also containing polyglutamine-expanded huntingtin protein characteristic for HD.
Especially in Slc9a6−/− (female) mice, affected neurons in mice as young as 8 weeks exhibited large amounts of densely stained material (Fig. 2A and B).
We next computed the contrast response functions with and without attention by averaging across the activity of all the significantly affected neurons (Fig. 5 D ).
For example, a subacute ischemia may leave affected neurons with injured but still partially functioning mitochondria, therefore, generating sufficient ATP levels to allow apoptosis to fully develop.
A prominent feature of AD is the accumulation of autophagosomes, many containing amyloid-β peptide, in massive numbers within affected neurons [ 22], probably reflecting defective autophagosome clearance [ 23].
Diffuse degeneration affected neurons in the hippocampus and thalamus (layer CA1, CA3) and their connections (efferent CA1 pyramidal axons, mossy fibres, Schaffer collaterals and the perforant path), as well as the corpus callosum and visual cortex (Hall et al., 2005).
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Injury-affected neurons start to express isoforms of the Flower cell fitness indicator protein not found on intact neurons.
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