Developmental abnormalities may affect isolated or multiple regions of the skeleton, or they may involve a specific tissue system; the latter are often hereditary.
To the Editor: Bolivian hemorrhagic fever (BHF) was first described in 1959 during outbreaks affecting isolated human communities in eastern Bolivia.
As the above results suggested that edelfosine interacted with mitochondria in HeLa cells, we analyzed whether this drug was able to affect isolated mitochondria.
In general, window-based techniques treat observations from individual genetic markers, often single nucleotide polymorphisms (SNPs), as samples that are representative of a phenomenon that affects isolated regions of the genome instead of independent SNPs.
Acetate can also affect isolated mitochondria independent of its oxidation, where Lehninger and others have demonstrated that exposure to acetate causes a rapid increase in mitochondrial matrix Ca2+ and osmotic swelling [ 13- 15].
Beyond the individual level of analysis, and following Bronfenbrenner's [ 14] bioecological system theory, it is likely that mass trauma does not only affect isolated individuals but also communities and families.
We note and emphasize that the window size we used (10k of accumulated exonic sites called for SNPs) is likely too coarse grained for detecting positive selection affecting isolated genes.
We consider the likelihood of the same contaminant affecting isolates maintained in three separate laboratories to be very small.
We have also shown that isolates with different SNP profiles can be affected by the same IS disruptions, and conversely, different IS disruptions can affect isolates with the same SNP profiles.
Patients affected with isolated glucocorticoid deficiency, a hallmark of hypopituitarism, usually retain a normal volemic status, in contrast to patients with primary adrenal insufficiency.
