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The phrase "affect the vast majority" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a large number of people or a significant portion of a group.
Example: "The new policy is expected to affect the vast majority of employees in the organization."
Alternatives: "impact most people" or "influence a large number".
Exact(17)
This proposal is not going to affect the vast majority of offenders".
In regulatory documents, they repeatedly assured banks that the regulations would not affect the vast majority of them.
Also, he said, divestment does not affect the vast majority of citizens, most of whom are poor.
"It is amazing how a small lawless minority in the city can affect the vast majority of citizens who pay their council tax".
We identified that woody encroachment and current disturbances affect the vast majority of kurgans, posing a serious threat to grassland specialist species.
So now they must be consistent and make their feelings known about the charges that affect the vast majority of their fans.
Similar(43)
Any Coalition pain at the ballot box over super was due to misinformation about how the policy affects the vast majority of voters.
Elderly patients are confronted with widespread and systematic inadequate care during their stay, which is a significant problem affecting the vast majority of hospitals in England, it says.
It's the most far-reaching tax hike in the deal, affecting the vast majority of the middle class and working poor, and it will lower GDP growth by 0.6percentt as a result, according to JPMorgan's chief economist Michael Feroli.
While alcoholism – where you become physically dependent on alcohol and experience withdrawal symptoms if you stop – is not something that affects the vast majority of students, many more may be abusive in their use of alcohol.
McLaren adds that "every [positive] sample was sent up the chain of the command" so the system in place at the Moscow lab would have affected "the vast majority of sports".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com