The phrase "affect the specificity and" is correct and usable in written English.
It can be used in contexts discussing how certain factors influence the precision or detail of something.
Example: "The changes in the experimental conditions may affect the specificity and accuracy of the results."
Alternatives: "influence the precision and" or "impact the detail and".
To ensure that the in vivo biotinylation did not affect the specificity and subsequent folding of the MHC class I complex, we compared the peptide binding affinities of HLA-HLA-A*0201-HAT-BSP HLA-HLA-A*0201-HAT-BSP HLA-HLA-A*0201-HAT-BSP HLA-HLA-A*0201-HAT-BSP HLA-HLA-A*0201-HAT-BSP
Direct injection methods can be affected by ion suppression, the presence of undesirable additional peaks, and noisy baselines that may affect the specificity and sensitivity.
It is currently unknown if these upgrades affect the specificity and sensitivity of variant detection in clinical data and how the TSVC performs when compared to open source variant callers that do not consider flow signal information.
Although a lower cutoff value could yield a higher sensitivity and negative predictive value (Table 3), it negatively affected the specificity and positive predictive value.
This process is inherently prone to variability that affects the specificity and sensitivity of the assay, thus requiring evaluation of each microarray data set [ 9, 10, 12].
Serial measurements of proBNP levels were available in 44% of our patients (data not shown), but the presence of pre-treatment proBNP levels above the age-adjusted cut-off values, and their variations due to cardiological therapy, anaemia, infections and renal disease, affected the specificity and predictive value of this biomarker, as previously reported (Dodos et al, 2008).
Variants that alter the DNA-binding specificity of transcription factors could affect the specificity for and expression of potentially many target genes, as has been observed in several tumor-derived mutations.
By simultaneously studying the effects of variation within the RE, within the TF, and between the two molecules were we able to describe in detail how changes in the TF protein affect the specificity of RE binding and vice versa.
In this work, by comparing the kinetic properties and the thermo-stabilities of the mutants with those of the wild-type enzyme, we confirm that the size of the residue at position 441 greatly affect the specificity for betaine aldehyde, and conclude that the acquisition of the new BADH function occurred without detriment of either the oxidation of other aminoaldehydes or the protein stability.
In addition, anti-tubulin and anti-HDAC6 activity might result in adverse side effects on human host functions and thus affect the specificity of the primary drug.
