The phrase "affect the specification of" is correct and usable in written English.
It can be used when discussing how certain factors or variables influence or change the details or requirements of a specification.
Example: "Changes in market demand can significantly affect the specification of the product we are developing."
Alternatives: "influence the specification of" or "impact the specification of".
The failure to restrict Nodal expression to the posterior of the embryo is likely to lead to a lower threshold of Nodal signalling in this region of the embryo as the Nodal/Wnt3 amplification loop is disrupted, and this lower threshold of signalling will affect the specification of the anterior primitive streak derivatives that require the highest levels of signalling.
It remains to be clarified whether other factors affect the specification of other interneuronal subsets in a non-cell-autonomous manner.
Therefore, Tribolium gap genes can affect the specification of segments that are not yet formed, presumably because of interactions with the growth zone.
Thus, loss of nf1a and nf1b does not affect the specification of OPCs at 2 dpf, but instead promotes the progressive expansion of OPCs without a concomitant increase in neuronal cell numbers.
Here we investigate: 1) how identification assumptions affect the specification of SEMs, 2) whether the more restrictive SEM assumptions can be relaxed, and 3) whether existing sensitivity analyses can be extended to this setting.
Mutations in cell cycle-related genes has also been shown to affect the specification of daughter cell fate, as well as the inappropriate self-renewal of neural progenitors rather than differentiation [ 80].
Thus, among the R cells, D-cbl specifically affects the specification of R7.
TEAD4 inactivation in mice severely affected the specification of trophectoderm, a precursor of placenta.
On this basis, we plausibly assume that the HD-induced overexpression of nodal similarly affected the specification of pigment cells in HD-expressing embryos.
Interestingly, shd and tra show very similar reductions in melanophores, despite the fact that shd affects the specification of iridophore precursors whereas tra leads to the death of differentiated iridophores.
Our findings suggest that disruption of C2CD3-dependent ciliogenesis does not affect the specification or proliferation of CNCCs, but does cause aberrant CNCC migration and differentiation.
