The mutation should produce a bulge, which will change the structure of the stem of the precursor miRNA, and will likely affect the site of Drosha cleavage in producing pre-miR-502 pre-miR-502 pre-miR-502
These APP-targeting manipulations may alter APP conformation, its positioning within the membrane, APP substrate presentation to γ-secretase, and/or stabilize PS1 in a certain conformation, and thus affect the site of APP cleavage by γ-secretase.
In light of our data, it would be tempting to hypothesize that the modification of C181 and C184 of H-Ras through the addition of electrophilic endogenous mediators or chemical agents could differentially affect the site of action of this GTPase depending on the structure and/or hydrophobicity of the bound molecule.
Thus it seems likely that the modifications resulting in maturation of 37LRP to 67LR directly, or indirectly, affect the sites of interaction with laminin.
Prevention and mitigation of wildlife fatalities, and protection of peat bogs, affect the siting and operation of wind turbines.
These data demonstrate that in RNA's with very different cellular functions, there are domains with similar structural and functional properties and that there is a nucleotide in M1 RNA that affects the site of cleavage by the enzyme.
However, the conversion affects the sites of interaction with both laminin and heparan sulfate.
The effects of extracellular [Ca2+] deprivation and CaCCH1 deletion primarily affected the site of germ-tube emergence.
This high rate of lead-related adverse events may be explained by the peculiar ARVC/D pathobiology which leads to progressive loss of myocardium with fibrofatty replacement, also affecting the site of RV lead implantation.
In this paper, we show that there are differences across individuals in the extent of inhibition at a particular synapse and that this affects the extent of recruited polysynaptic excitation, which in turn affects the site of action potential initiation and subsequent direction of propagation.
