Sentence examples for affect the regulation and function of from inspiring English sources

Considering that sequence variants in the noncoding region may also affect the regulation and function of genes and the difficulty of functional characterisation of various CYP1B1 isoforms in vitro, analysing multiple SNPs simultaneously may provide more direct evidence for the relationship between cancer risk and the genetic polymorphisms in CYP1B1.

The effects of endocrine-disrupting chemicals (EDCs) on the sex steroid system have attracted the most attention over the past decades, with reports that environmental contaminants act either as estrogenic, androgenic, anti-estrogenic or anti-androgenic agents and consequently affect the regulation and function of the reproductive system and sexual development [9], [10].

Based on their molecular identities, strong loss-of-function phenotypes, and likely modes of action, there appear to be several pathways that function cumulatively to affect the regulation of meiotic maturation downstream of PKA.

Nanotopography might affect the constructs and functions of astrocytes, leading to the regulation of hyperexcitability and epileptic activity in neurons.

Moreover, these receptors function as nutrient sensors to affect the regulation of genes involved in metabolism and energy homeostasis.

Thus, histone deacetylation appears to also function at a step(s) down-stream of gene regulation induced by liganded TR to affect the regulation of genes involved in the subsequent steps important for adult intestinal stem cell formation.

Our results here unveil a novel role for flotillin-1, as a scaffolding protein affecting the regulation of membrane ion channel function.

To ask how the impaired Sin3A co-repressor function affects the regulation of genes commonly deregulated in Sin3A-deficient and Hdac1Δ/Δep Hdac2Δ/+epidermismis, we performed chromatin immunoprecipitation (ChIP) assays.

Arabidopsis polyadenylation factor PCFS4 has been shown to function in the alternative polyadenylation of FCA pre-mRNA and therefore affects the regulation of flowering time [13].

Importantly, altering the function and/or abundance of any of the telomere-binding proteins affects telomere length regulation and function (i.e., prevention of a DNA damage response at telomeres).

Thus, by affecting wiring and function of specific hypothalamic neurons leptin may directly be involved in the regulation of an organism lifespan.