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This can lead to under- or overestimation of the parameter estimates, which may affect the prognostic ability of the covariates and change the study's conclusions.
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The overall high level may affect the prognostic significance of serum albumin.
In addition, the shorter follow-up period of the validation set than the training set might adversely affect estimation of the prognostic ability of lymph node status.
Because the 'cell death' signature contained some genes that also had roles in processes that might be expected to affect metastasis, i.e. cell migration and invasion, we assessed the prognostic ability of genes with a 'cell movement' annotation compared with the remainder of the signature.
Moreover, it is necessary to test the prognostic ability of markers in diverse datasets to avoid dataset-specific affects.
The prognostic ability of a single measurement of peak oxygen uptake (VO(2)) is well established in patients with chronic heart failure.
The composite characteristics of Pv aCO2/Ca vO2, however, suggest that the prognostic ability might be mainly related to the interaction of several mechanisms, not only to anaerobic metabolism.
Bruck et al. compared the prognostic ability of 11C-PiB PET, 18F-FDG-PET, and quantitative hippocampal volumes measured with MR imaging in predicting MCI to AD conversion.
There are however limited data on the prognostic ability of IGRAs to predict the development of active TB disease.
Fan and colleagues [ 25] recently compared the prognostic ability of the intrinsic subtypes and four prognostic signatures in 295 patients.
The prognostic ability of the APACHE II model [ 10] was assessed in the four defined groups.
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