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While Gremlin expression may be regulated by FMN1, knockdown of Gremlin by siRNA plasmid might not affect the expression and function of FMN1.To date, no evidence suggests that Gremlin regulates Fmn1.
Further expression studies are required to confirm whether these mutations affect the expression and function of these virulence factors.
SNPs in miRNA may affect the expression and function of mature miRNA and thereby influence individual susceptibility to cancer [ 13– 15].
Two other genes in the rck operon, pefI and srgA, appear to affect the expression and function of the pef operon which encodes socalled plasmid-encoded fimbriae [ 9, 11, 12].
Polymorphisms in the promoter region as well as in the transmembrane domain of the FcγRIIb gene have been described to affect the expression and function of this receptor, respectively [ 10- 12].
The genetic defects that cause PIDs can affect the expression and function of proteins involved in a range of biological processes, such as immune development, effector-cell functions, signaling cascades and maintenance of immune homeostasis.
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Thus, the expression and function of nuclear genes should be affected in various ways by chloroplast and mitochondrial genes.
Alternatively, activity could affect the expression, function or subcellular localization of TRIM3, thereby stimulating GKAP ubiquitination-degradation.
In addition, AtKDM1B and AtKDM1C can also affect the expression of FWA, a function independent of that of AtKDM1A.
These epigenetic marks affect the structure and function of chromatin, thereby regulating gene expression and can be identified by immunolocalization (Bannister and Kouzarides [2011]).
Different miRNAs have also been shown to affect expression and function of other antiapoptotic proteins of the Bcl-2 family.
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