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Strong CYP1A induction following FEN therapy in pigs may negatively affect the efficacy and pharmacokinetics of FEN itself or other simultaneously or consecutively administered drugs.
Drugs possessing the ability to bind to melanin-rich tissue, such as the eye, are linked with higher ocular exposure, and therefore have the potential to affect the efficacy and safety profiles of therapeutics.
Body composition is an important feature in cancer patients as it may affect the efficacy and toxicity of chemotherapy, and it is associated with patient outcomes in terms of functional status, surgical complication rates, length of hospital stay (LOS) and overall survival (OS) [1, 2, 3, 4, 5, 6, 7, 8].
However, MTHFR gene polymorphisms also affect the efficacy and toxicity of chemotherapeutics [ 37].
The carbohydrate composition of a meal can also affect the efficacy and tolerability of acarbose therapy.
The three components of ADCs (mAb, linker and cytotoxin) affect the efficacy and toxicity of the conjugate.
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Nevertheless, most of the chip companies agree that the next big application will be the interpretation of how genetic diversity affects the efficacy and side effects of drugs, a field known as pharmacogenetics.
To determine whether the technique used affects the efficacy and safety of the product, this review of evidence had the goal of identifying and establishing a preferred method of applying INS sprays.
Whether this happens in other tumor types as well and how this affects the efficacy and toxicity of subsequent RTx should be further addressed.
Some tumors develop resistance to VEGF inhibitors by secreting cytokines that recruit myeloid cells and other cells that promote angiogenesis and immune tolerance, thereby affecting the efficacy and safety of anti-VEGF therapy [ 9].
Particularly, the aforementioned specialized physiology of the brain not only contributes to the colonization of metastatic tumor lesions but also significantly affects the efficacy and outcome of therapeutic interventions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com