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We therefore considered the possibility that a subset of WS genes might act in cellular processes that affect the development and function of both the brain and the immune system.
Tryptophan depletion is known to affect the development and function of the hippocampus [ 69- 71].
Increased glucocorticoid levels during the fetal period may affect the development and function of the lungs during early life [ 42].
Many of the genes affect the development and function of the nervous system, and are thus plausibly relevant to the execution of complex behaviors.
Changes in these signal transduction pathways can lead to differential gene regulation with subsequent changes in protein expression, which can affect the development and function of the nervous system.
An extensive scientific literature, composed of studies evaluating the potential for physical, pharmaceutical, and environmental agents to affect the development and function of the nervous system after prenatal and early post-natal exposure, provides a strong foundation for guideline development, implementation, and validation.
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The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells.
These mice enabled us to determine how physiological MDM2 expression in normal tissues affected the development and function of T cells specific for this TAA.
Genes involved in the development and function of the nervous system were also affected by IHNV exposure.
It has been supposed that particular DTNBP1 alleles increase the risk for schizophrenia and affect cognitive functions mediated by the glutamate neurotransmitter system directly affecting the development, maturation, and adult function of the prefrontal cortex [ 54, 58, 59].
However, it has not been fully elucidated how aging affects development and function of LCs.
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