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The phrase "affect the appropriateness of" is correct and usable in written English.
You can use it when discussing how one factor may influence the suitability or relevance of another factor in a given context.
Example: "The cultural background of the audience can significantly affect the appropriateness of the content being presented."
Alternatives: "influence the suitability of" or "impact the relevance of".
Exact(7)
Furthermore, ethnic differences have been described in A1C levels, [8], [9], [10], [11] which may affect the appropriateness of A1C in LMIC settings.
Not only may this vascular model be inadequate for tumors, but also it is unclear how anti-angiogenic tumor therapies that normalize the tumor vasculature will affect the appropriateness of such a fixed vascular model.
The degree and form of brain injury can affect the appropriateness of analytic treatment.
It is unknown what the rate of attendance at the intervention will be, and this could also affect the appropriateness of the chosen sample size.
Inpatient consultation by an infectious diseases specialist did not affect the appropriateness of home vancomycin prescriptions by managing services (p = 0.641).
Since the issues in the management of LBP are likely to be similar in all parts of the UK, this should not affect the appropriateness of the package for our current purpose.
Similar(53)
When an antimicrobial is prescribed uniform use of nitrofurantoin (except when contraindicated) would reduce drug cost without affecting the appropriateness of treatment.
Good perceived wealth may indicate access to better quality material resources such as healthy foods, whereas the absence of good perceived wealth may negatively affect the appropriateness and diversity of choices.
We also examined how alternatives to our expert panel's judgment would affect the appropriateness ratings for the treatment of children with acute otitis media.
Notwithstanding this, a note of caution is warranted as the ranking of candidates here, could be affected by the appropriateness of the InterDom [ 41] and the score it provides, as the interaction networks are neither complete nor error free.
Further, clinical procedures are stressful and a person's internalized cultural norms affect the appraisal process of stressors and the perceived appropriateness of coping responses [ 17].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com