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Among factors which can affect neurotoxic outcomes, age is considered the most relevant.
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In the present study, we considered whether the anesthetic protocol could affect the neurotoxic action of a glutamate agonist in vivo.
Specific serotonergic projections of the dorsal and median raphe nucleus to hypothalamic, frontal and occipital areas are affected by neurotoxic agents like Ecstasy, and, therefore, are implemented in modulating attention, memory and executive tasks [24], [25].
At present, we can only speculate about which parts of an infant's CNS might be affected by neurotoxic substances.
These results indicate that the brain development of the fetuses may have been affected by neurotoxic events similar to ionizing radiation.
These studies showed that neurotoxic compounds affect behaviour and movement in C. elegans.
Neurotoxic substances affect the nervous system in a selective manner.
At the mitochondrial level, such neurotoxic actions affect the components of the OXPHOS by depletion of ATP levels (Ref. 64), and they exert a secondary effect on the mitochondrial ATPase.
In contrast, modified Trp affected only the neurotoxic effect caused by MjTX PLA2-II [ 60], indicating the relevant role of this residue in this activity and suggesting that chemical modification could be interfering with the stability of the interaction between the monomers of this dimeric toxin, since Trp77 helps to maintain the homodimeric interaction.
The direct neurotoxic affects of Aβ42 oligomers [ 2, 3] include reductions in glutamatergic synaptic transmission and plasticity and attenuation of excitatory synaptic transmission by decreasing the number of surface AMPA and NMDA receptors associated with a collapse of glutamatergic dendritic spines.
Dr. Margolis is the recent recipient of an NIEHS funded K Award to study how exposure to neurotoxic chemicals may affect neurodevelopment and manifest as subsequent learning and social problems.
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