Expansion of intronic trinucleotide repeat GAA in the Fxn gene results in Friedreich ataxia, a mitochondrial disorder affecting multiple systems of organs, including the visual pathway [ 5].
Burn injury affects multiple systems of the body including the immune, metabolic and endocrine systems, and the pathophysiological mechanisms that underlie the different musculoskeletal conditions discussed in this paper are most likely variable.
Complications of diabetes as a result of oxidant stress affect multiple systems throughout the body, but involvement of the cardiovascular system may be one of the most severe in light of the impact upon cardiac and vascular function that can result in rapid morbidity and mortality for individuals.
Due to the presence of multiple active compounds in phytomedicines they are an ideal candidate for treating conditions with a variety of symptoms such as inflammatory diseases which affect multiple systems.
Because SATB2 is highly conserved between species (99.6% between humans and mice), a deletion of this gene in humans is predicted to affect multiple systems.
Diabetic autonomic neuropathy is frequent and can affect multiple systems, including cardiovascular, gastrointestinal and genitourinary.
However, aging may affect multiple systems and functions concomitantly.
After accessing the interaction frequency between any two SOCs, we found that SOCs frequently interacted with other SOCs rather than themselves, indicating that perturbation to a certain pathway may affect multiple system organs instead of one specific organ.
A successful example of the therapeutic use of a glycan for the treatment of a clinical defect is the oral administration of mannose for the treatment of congenital mannosyl transferase deficiency, a congenital metabolic disease affecting multiple systems, including the nervous system of infants [41].
Cornelia de Lange Syndrome is a severe genetic disorder characterized by malformations affecting multiple systems, with a common feature of severe mental retardation.
