Sentence examples for affect multiple components of from inspiring English sources

To choose the loci for validation, we assessed the candidacy of the top 56 loci in terms of related biological function, reasoning that epigenetic dysregulation of the small degrees we were observing would have to affect multiple components of a biological pathway to cause functionally-significant changes.

In this study, we provide evidence that inactivating genetic alterations affect multiple components of the CUL3/KEAP1/RBX1 E3-ubiquitin ligase NRF2 inhibitory complex in a remarkably high number of OVCA cases.

These data suggest that most of serine proteinase activities secreted in vitro by infective larvae of T. canis have intriguing nature but otherwise help the parasite to affect multiple components of somatic organs and bodily fluids within the infected host.

Like other invasive species of deciduous forests (Ehrenfeld et al. 2001; Poulette and Arthur 2012; Smith and Reynolds 2012; Kuebbing et al. 2014; Schuster and Dukes 2014), Alliaria can affect multiple components of the soil environment.

Rather, it suggests that the overall process is likely complex and that paraoxon may affect multiple components of the cholesterol efflux machinery, including several other candidates that catalyze cholesteryl ester hydrolysis that are known to exist.

Our imaging and FT Raman data suggest that the presence of ferrous ions during sulfuric acid pretreatment may affect multiple components of the plant cell wall, including the C-O-C and C-H bonds in cellulose.

A chronic state of impaired glucose metabolism affects multiple components of the immune system, possibly leading to an increased incidence of post-operative infections.

Perhaps the best example is a group of patients with biochemical defects affecting multiple components of the mitochondrial respiratory chain due to a disorder of intra‐mitochondrial protein translation (Rotig, 2010; Kemp et al, 2011; Hallberg & Larsson, 2014; Taylor et al, 2014).

Light and inhibition of CK1δ/ε simultaneously affect multiple components in the molecular feedback loops in circadian clocks.

Because of the intrinsic nature of miRNAs, several mRNA targets may be downregulated by a single mature molecule, increasing the likelihood of affecting multiple components within a biological pathway.

SWT and its components, by affecting multiple Nrf2 target genes, could impact multiple components of the carcinogenic process.