The phrase "affect its localization to" is correct and usable in written English.
It can be used when discussing how something influences or changes the specific location or positioning of an object or concept.
Example: "The new software update may affect its localization to various regions, ensuring better performance in different markets."
Alternatives: "influence its positioning to" or "impact its placement to".
Similarly, ubiquitylation of paxillin was shown to affect its localization to focal adhesions and to inhibit cell migration [ 13].
In addition, its glutathionylation may affect its localization to the extracellular compartment, along with Trx, thereby inducing TNFα production leading to an oxidative stress-dependent inflammatory reaction [ 65].
DOI: http://dx.doi.org/10.7554/eLife.07366.013 Because inhibiting the catalytic function of VCP leads to tubule deterioration, we tested whether inhibiting the catalytic function of VCP would affect its localization to auto-lysosomes.
As shown in Fig. 4, neither G275S nor G173R mutation in RPGR1 19 alone affected its localization to the ER, whereas their co-expression with RPGRIP1α1 led to the targeting of RPGRIP1α1 to such subcellular region, where it co-localized with either mutant RPGR1 19 protein.
To determine if an increase in stability of ADAR2 would affect its localization, immunofluorescence was performed in Pin1+/+ and Pin1−/− MEF cells and were transiently transfected with ADAR2 PPxY.
We next tested if mutating the TBM in SLX4 affects its localization at telomeres.
These observations indicated that interaction of ORF33 with other virion protein(s) may affect its localization during viral infection.
In comparison with the apical localization of the IAA signal in the control plants, Zn generally reinforced the intensity of IAA signal, without affecting its localization.
Sgol2 decreases Aurora C activity at the kinetochores without affecting its localization.
The deletion of the region immediately C-terminal to the zinc-fingers (residues 391 655) similarly abolishes Gli1 ciliary localization, but does not appear to affect its cytoplasmic localization (Fig. 2A, D; Table 1; n = 0/35).
Speculation exists that BRCA1 phosphorylation may affect its cellular localization and stability as well as altering its ability to bind other proteins and thus, affect its biochemical activities as they are related to DNA damage repair or gene transcription [16].
