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The phrase "affect him deeply" is correct and usable in written English.
It can be used when describing a strong emotional impact or influence on someone.
Example: "The news of his friend's passing will affect him deeply, leaving him in a state of sorrow."
Alternatives: "move him profoundly" or "touch him emotionally."
Exact(2)
The experience seemed to affect him deeply.
In the intervening decades she had done a much better of job than me of keeping in touch with Scott – so I knew that the news would affect him deeply.
Similar(58)
The trip affected him deeply.
The episode affected him deeply.
The violence affected him deeply, however.
The creative process affected him deeply.
That is something Messi admits affects him deeply.
Bergman's death in 2007 affected him deeply.
Problems in the extended family also affected him deeply.
"I believe that it affected him deeply," she said.
What he saw there, he will tell you, affected him deeply.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com