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Another example are de-methylation inhibitors (DMI fungicides, FRAC group G1) that are designed to interfere with cytochrome P450 monooxygenases in target fungi but can affect diverse and different biochemical pathways in various species and thereby display different modes of actions in non-target organisms [27].
As mitochondria are present in all cells of the body, mitochondrial disorders have very complex manifestations that can affect diverse organs such as the heart, the endocrine system (causing, for example, diabetes), and, for reasons not always well understood, some but not other aspects of brain function.
Altogether, this network analysis suggests the possibility that the RA effects on hMSC that affect diverse cellular properties of hMSC are mediated by ERK dependent pathways.
These results highlight the similar binding properties of Lrig1 and Lrig3 and underscore the need to determine how these two family members bind to and regulate different receptors to affect diverse aspects of cell behavior in vivo.
The identification of the molecular targets that are affected by SIRT1 phosphorylation, especially at sites modified by cell cycle-dependent kinases like Cdk1, will help to elucidate how changes in the level and activity of SIRT1 affect diverse processes such as growth and longevity in organisms ranging from single-celled yeast to mammals.
Similar peptides affect diverse physiological pathways in different species or even within the same organism.
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Sumoylation is a post-translational modification affecting diverse cellular processes including DNA replication and repair, chromosome packing and dynamics, genome integrity, nuclear transport, signal transduction and cell proliferation [1].
Furthermore, bioinformatics analyses of differentially regulated genes and miRs have shown that TWEAK affects diverse cellular responses such as proliferation, musculature development, inflammation, and adipocyte formation.
Inhalant abuse is widespread and affects diverse groups in domestic and international populations.
In these approaches, dialysis modality was implicitly considered as a fixed factor affecting diverse clinical outcomes.
HGPS affects diverse body systems including skeleton, body fat, skin, hair and the cardiovascular system.
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