Sentence examples for affect binding affinity from inspiring English sources

TSPO binding was quantified as total distribution volume of [11C]PBR28 in grey matter, controlled for polymorphisms in the TSPO gene that affect binding affinity.

The molecular determinants of drug receptor binding kinetics remain poorly understood, however, especially when compared with the well-known factors that affect binding affinity.

Consistently, also a triple mutation failed to associate with RIPK2, whereas an unrelated mutation (R132Q) outside the anticipated interaction interface did not detectably affect binding affinity.

We favor the view that conformational differences imposed by the CH1 domain on the Ag-binding site could affect binding affinity and specificity.

How does phosphorylation of the SPSP motif of SF1 affect binding affinity toward U2AF?

Thus increasing or decreasing net charge of HA would alter electrostatic interactions which in turn affect binding affinity.

As a result, hydrogen bonds are either present or absent, preventing prediction of how subtle changes in these patterns and frequencies will affect binding affinities.

Local eQTL are largely thought to regulate proximal genes by affecting the activity of regulatory elements that directly influence transcription rates, such as through alterations in genomic sequence that affect binding affinities of regulatory factors.

The neutralizing motif indicates that conservative replacements at positions 430 (N→Q), 431 (D→E) and 438 (L→I) will likely not affect binding affinities sufficiently to abolish neutralization.

This represents a greater than 50-fold reduction in binding affinity relative to the parent phosphotyrosine-containing peptide, indicating that the aryl nitrogen adversely affects binding affinity.

Furthermore, a molecular docking study was performed to obtain a better insight as to at which position such azide handles could be tolerated without affecting binding affinity.