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The phrase "affect almost all" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a large majority of a group or population.
Example: "The new policy changes will affect almost all employees in the organization."
Alternatives: "impact nearly everyone" or "influence the vast majority".
Exact(41)
Briefly, glucose was found to affect almost all the important genes involved in auxin biosynthesis, perception, signaling and transport.
This is not surprising, because they affect almost all of us occasionally.
Some mutualistic relationships are so pervasive that they affect almost all life-forms.
Atrophic changes of aging affect almost all tissues and organs, but some changes are more obvious and important.
The cutbacks will affect almost all levels of employees, from a division president to on-air news reporters to secretaries.
According to the Pentagon, these could come to more than $55 billion and will affect almost all major weapons programs.
Similar(19)
The motor industry is suffering more than other sectors from the effects of the current international crisis with a widespread drop in sales affecting almost all the main world producers, due to two factors that can be described as follows.
Leptospirosis is globally important infectious disease affecting almost all mammals.
Fire affects almost all of them however, at some scale!
Nitric oxide (NO) participates in inflammation and affects almost all steps of its development.
President Trump's version affects almost all global health assistance — a full $8.8 billion.
More suggestions(4)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com