The phrase "affect a substantial proportion" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a significant number of people or things.
Example: "The new policy is expected to affect a substantial proportion of the workforce, leading to changes in job roles and responsibilities."
Alternatives: "impact a significant portion" or "influence a large segment".
Second, a newly released drive will typically take dozens of generations to affect a substantial proportion of a target population, unless drive-containing organisms are released in numbers constituting a substantial fraction of the population.
In conclusion, this study suggests that drug stock-outs affect a substantial proportion of patients on cART in Abidjan, even though generic the fixed-dose recommended as first-line therapy in Côte d'Ivoire, stavudine/lamivudine/nevirapine, was always in stock.
In some rivers or hydroelectric schemes, predation may affect a substantial proportion of the fish population.
Joint injury and disease are painful and debilitating conditions affecting a substantial proportion of the population.
Affecting a substantial proportion of adults, chronic kidney disease (CKD) is considered a major risk factor for cardiovascular (CV) events.
CONCLUSIONS: Criminal justice involvement is a complex and costly problem that affects a substantial proportion of adults with serious mental illness who receive services across state agencies.
Chronic kidney disease (CKD) is a common condition, affecting a substantial proportion of adults in the U.S. and worldwide (1).
IBS, a functional bowel disorder, is a common problem affecting a substantial proportion of the population, with point prevalence estimates ranging from 10-30% [ 2- 10].
Irritable Bowel Syndrome (IBS) is a chronic, relapsing, gastrointestinal disorder, affecting a substantial proportion of the population, with recent prevalence estimates between 10.5% and 30% [ 1- 4].
Please see related research by Salluh et al, http://ccforum.com/content/14/6/R210 Delirium affects a substantial proportion of hospitalized patients and increases their likelihood of unfavorable outcomes.
Gestational diabetes (GDM) affects a substantial proportion of women in pregnancy and is associated with increased risk of adverse perinatal and long term outcomes.
