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The phrase "affect a significant proportion" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a large part of a population or group.
Example: "The new policy is expected to affect a significant proportion of the workforce, leading to changes in job roles and responsibilities."
Alternatives: "impact a large segment" or "influence a considerable share".
Exact(1)
Although the suggestive associations we observed are small, within 10% of null, a small effect size could affect a significant proportion of the population because of the ubiquity of these exposures and by their high levels (micromolar) observed in urine of the BCERC cohort.
Similar(59)
Type 2 diabetes affects a significant proportion of the population in North America, with an incidence directly proportional to the development of obesity (1).
Pandemic, outbreak of infectious disease that occurs over a wide geographical area and that is of high prevalence, generally affecting a significant proportion of the world's population, usually over the course of several months.
Regrettably, we also have evidence that the burden from alcohol and other drugs has increased in many countries; the burden from tobacco smoking, although still affecting a significant proportion of the population, has fallen.
Hypothyroidism is a common endocrine condition that affects a significant proportion of individuals worldwide.
Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population.
Social isolation affects a significant proportion of older people and is associated with poor health outcomes.
Alcohol misuse remains a major health and social problem in the UK affecting a significant proportion of the population.
Poor response to ovarian stimulation affects a significant proportion of infertile couples undergoing in vitro fertilisation (IVF) treatment.
Low back pain (LBP) is a condition that affects a significant proportion of the population, with a lifetime incidence rate in excess of 70% in industrialised nations [ 1].
Peripheral diabetic neuropathy is a common and potentially disabling complication affecting a significant proportion of patients with either type 1 or type 2 diabetes [ 1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com