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The phrase "affect a large number" is correct and usable in written English.
It can be used when discussing the impact or influence of something on a significant quantity of people, objects, or situations.
Example: "The new policy is expected to affect a large number of employees across the organization."
Alternatives: "impact a significant number" or "influence a considerable amount".
Exact(57)
Does it affect a large number of people or a small number?
"I've always wanted to be a producer for a major TV network and work on stories that affect a large number of people.
What is clear is that noise pollution does affect a large number of people and is a significant risk to their health.
Molly Broad, president of the American Council on Education, which represents 1,600 colleges and universities, said: "A widespread credit crisis will affect a large number of our institutions very quickly.
"We've tried very hard here to make something that will not affect a large number of people who were concerned about it," said one of the bill's sponsors, Councilman G. Oliver Koppell of the Bronx.
The A. A. P. takes the position that guns are a public health issue and that pediatricians have a duty to ask about ownership because firearm injuries affect a large number of their patients.
And lastly there's the fact that major events such as childbirth or divorce or becoming a carer, the kind of events that are likely to affect a large number of us as at some point or another, have a much greater impact on women's ability to save.
Marilyn Golden, a senior policy analyst at civil rights law organisation Disability Rights Education and Defense Fund (DREDF), says that while Leap's actions don't directly affect a large number of people and are not indicative of public transport generally, they are "symbolic".
"If we could figure out three or four of those behaviors that affect a large number of people and say, 'O.K., a lot of guys are doing this, how can we teach them to do that in a way that is more safe and more responsible?' " Some programs are already in place for young men and women who return from war feeling invincible.
So what are the key anti-avoidance features, which could affect a large number of people?
Fitbit is kicking the week off right with a slew of announcements that affect a large number wearable company's offerings.
More suggestions(15)
affect a vast number
affect a large proportion
affected a large number
effects a large number
effect a large number
are a large number
influences a large number
affecting a large number
concerning a large number
impact a large number
impair a large number
influence a large number
influencing a large number
afflict a large number
affect a large fishing
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com