The phrase "af pathway" is not correct in written English.
It appears to be a typographical error or a miscommunication, as "af" does not have a clear meaning in this context.
Example: "The research team is exploring the af pathway to understand its implications on cellular processes."
Alternatives: "a pathway" or "the pathway."
This may explain the specificity of AF pathway extrolite profiles (chemotypes) for specific Aspergillus taxa.
Equally unknown are the specific genomic mechanisms responsible for ordering and clustering of genes in the AF pathway of Aspergillus.
The aflatoxin (AF) pathway is one of the most intensively studied and well characterized of the polyketide pathways.
In general, there is conservation of gene order and direction of transcription for specific groups of two or more AF pathway genes.
Numerous intriguing ideas regarding the function of AF pathway gene products have been offered and studies indicate that the role of these compounds in the survival of Aspergillus spp. may be extremely diverse [ 35, 36].
Thus, there is increasing evidence that the 'indirect' human dorsal AF pathway identified by Catani et al. (2005), Catani et al. (2007) may involve more complex and fine-grained divisions.
Catani et al. (2005), Catani et al. (2007) postulated that the dissociable AF pathways were associated with separable linguistic functions, with the direct pathway underlying phonological processing and sound-to-motor mapping, and the indirect pathway supporting higher level lexical-semantic language processes.
This suggests the potential for increased signalling via an AF-6/PDZ-GEF2 pathway downstream of JAM-A overexpression in tumor cells.
The median haemolytic activity of the classical C pathway in AF (75 U ml−1) was within the range detected in NHS (50 100 U ml−1) (Table 3).
To demonstrate direct activation of the calcineurin pathway by AF, we assessed NFATc2 nuclear translocation by Western blotting and confocal microscopy.
In this regard, mitochondrial dysfunction represents a promising therapeutic target given its likely role as a common pathway mediating AF and HM via metabolic and oxidative stress in association with ATP depletion, disruption of ionic currents, and increased ROS generation [ 56– 56].
