The adverse prognostic value of shock and vasopressor dependency after ROSC is clear, although the contribution of PAMD to adverse outcomes remains uncertain.
The adverse prognostic value of ulceration in melanoma has two possible explanations.
An adverse prognostic value of postcontrast AKI has also been demonstrated for longer-term mortality [ 38].
Moreover, recent data have suggested an adverse prognostic value of CTC detection in nonmetastatic breast cancer [ 10– 10].
The adverse prognostic value of LRP may be important because it may influence early selection of TGCT patients for novel therapeutic strategies.
The most consistent data for an adverse prognostic value of a high Ki-67 have been reported for breast cancer (Baak et al, 2009), lung cancer, and sarcomas.
Individuals who are skeptical about the adverse prognostic value of NOD argue that NOD failed to translate into a prognostic disadvantage in most trials.
This model would account for non-uniform changes in CCSphase scores for the total gene dataset found in some breast cancer patients, the Whitfield et al.'s observation, and the adverse prognostic value of cyclin D1.
Only one publication has yet demonstrated the adverse prognostic value of cribriform growth pattern in a biopsy series, with radiotherapy as treatment, and biochemical recurrence as clinical endpoint [ 54].
Although the adverse prognostic value of enhanced VEGF expression has been shown in some studies (Zhang et al, 2007), others report conflicting results with higher microvascular density and VEGF expression predicting for a more favourable outcome (Couvelard et al, 2005).
