The phrase "adverse normal" is not a standard expression in written English and may cause confusion.
It could potentially be used in a specific context where contrasting "adverse" conditions with "normal" conditions is necessary, but it is not commonly recognized.
Example: "In the study, we observed the effects of adverse normal conditions on plant growth."
Alternatives: "unfavorable typical" or "negative standard".
However, radiation therapy can cause a range of adverse normal tissue responses, which can limit therapeutic doses delivered.
Much evidence supports a genetic basis for the predisposition to adverse normal tissue reactions after RT (McKay and Peters, 1997).
In the first case, a 50-year-old breast cancer patient had a severe late adverse normal tissue reaction to radiotherapy (Fang et al, 2010).
Although a variety of factors could theoretically influence radiosensitivity, strong evidence implicates a genetic basis for the predisposition to adverse normal tissue RT reactions.
Radiotherapy dose intensities are typically selected to avoid an unacceptable frequency of severe adverse normal tissue reactions and hence, most patients could potentially tolerate RT dose escalation.
Therefore, we analysed a relatively large cohort of 18 LCLs derived from RT patients who showed severe (RTOG⩾3) adverse normal tissue RT reactions and 11 non-RS control cancer patients.
Generally speaking, self-fertilization in orchids seems to be a means of averting extinction in plants growing under conditions adverse for normal pollination relationships.
To report on the tumor control, adverse late normal tissue sequelae, and functional performance in patients with tonsillar fossa and/or soft palate (SP) tumors.
Where the START trials showed that the principle of hypofractionation in breast cancer treatment was effective, the FAST trial investigated how much the dose per fraction could be increased before adverse acute normal tissue reactions became intolerably high.
The Kruskal Wallis test was performed to compare whether there was a difference in cumulative doses received between those who developed different grades of haematological adverse events (normal vs grade 1 2 vs grade3 4 vs haematological malignancy): this did not reach formal significance (P=0.067).
Therefore, vaccination of these peptides may not be associated with adverse events in normal cells and normal tissues.
