The phrase "adverse milieu" is correct and usable in written English.
It can be used to describe a negative or unfavorable environment or setting, often in contexts related to psychology, sociology, or health.
Example: "The study revealed that children raised in an adverse milieu often faced significant challenges in their development."
Alternatives: "hostile environment" or "unfavorable setting".
A possible reason for this improvement could be the shorter exposure to an adverse maternal milieu before they attempt fertilisation.
This in turn could explain the impaired endothelial vascular response observed in patients who were exposed to an adverse intrauterine milieu.
This is in keeping with the abnormal circadian blood pressure variability and endothelial function being functional markers for an adverse cardiometabolic milieu [ 8, 10].
One important factor influencing short- and long-term placental perfusion is hypoxia [ 11- 13], representing the most adverse intrauterine milieu for the foetus.
While reduction of circulating progenitors and endothelial progenitor cells (EPCs) in diabetes is much likely caused by impaired mobilization from the bone marrow [ 7]. dysfunction of circulating pro-angiogenic cells (PACs) results from the adverse metabolic milieu of T2D [ 8].
Overall, our study provides comprehensive evidence how an adverse intrauterine milieu directly influences human foetal gene expression by means of various levels of gene regulation in vascular endothelial cells, including CpG signalling, chromatin plasticity and non-coding regulatory RNA.
Low oxygen availability in the high altitude milieu causes adverse physiological and pathological consequences to the cardiopulmonary system.
These novel findings indicate that highly aligned tendon cell scaffolds not only promote tendon matrix synthesis, but also play a previously unappreciated role in mitigating adverse resident fibroblast response within an inflammatory milieu.
Anyway, it remains uncertain whether these conditions are primarily a result of an impaired renal clearance of inflammatory cytokines, direct stimulation of cytokine release by uraemic milieu or simply a consequence of an adverse effect of inflammation on RRF.
If successful, it could provide a novel and more acceptable strategy to protect against the adverse effects of an unhealthy diet typical for the nutritional milieu which modern humans have created for themselves and as such could contribute to improve metabolic health.
