Similar(60)
Primary cultured neurons derived from LRRK2 G2019S mutant transgenic mice exhibit increased growth cone size and reduced neurite outgrowth characterized by increased levels of F-actin in the growth cones (Parisiadou et al., 2009), suggesting an adverse gain-of-function effect of this LRRK2 mutation on neuronal plasticity.
76 Our findings further suggest that tree nuts do not have a significant effect on the most metabolically adverse weight gain involving an increase in waist circumference.
Current anti-diabetic medications often result in adverse weight gain and hypoglycemic episodes.
Firstly, good evidence shows that regular consumption of sugar sweetened drinks is associated with ill health principally, adverse weight gain, type 2 diabetes, cardiovascular disease, and dental caries.
In all studies, more subjects in the quetiapine group left the trials early due to adverse events (gained weight and sedation).
Hypoglycemia, weight gain, adverse events and unclassified reasons were much less important.
Only one patient in the overweight group discontinued due to a metabolic-related adverse event (weight gain) during the DB phase.
Youth with serious mental illness may experience improved psychiatric stability with second generation antipsychotic (SGA) medication treatment, but unfortunately may also experience unhealthy weight gain adverse events.
Children and adolescents, especially those who are antipsychotic-naïve, are at greater risk for unhealthy weight gain adverse events than adults [ 3, 5, 6], and they often gain over 7% baseline weight within the first few months of treatment [ 1, 7, 8].
Weight gain, adverse event rate and number of hypoglycaemic episodes were also low and similar between the SimpleSTEP and ExtraSTEP strategies, although, as might be expected, hypoglycaemia frequency increased with increasing number of prandial injections, from one to three, in both groups (SimpleSTEP: 6.2 to 14.7 events/year; ExtraSTEP: 5.6 to 13.0 events/year).
The adverse effect of gaining weight on sleep-disordered breathing was clear from the 4-year Wisconsin Sleep Cohort Study (6): a 10% increase in weight, in comparison with a stable weight, was associated with a 32% higher increase in AHI and a sixfold risk of developing moderate to severe obstructive sleep apnea; a 10% decrease in weight was associated with a 26% decrease in the AHI.
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