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Whereas older drugs may have been used in pregnancy without any signal of fetal harm, often little is known about the fetal risk of newer preparations, which may be preferred for the mother due to improved efficacy or adverse effect profiles.
Due to the multiple options of therapy available for ART-naive patients, providers initiating PI-based ART can individualize therapy based on patient characteristics and needs, including pre-treatment resistance, drug-drug interactions, adverse effect profiles and co-morbid conditions.
Different adverse effect profiles between the arms, for example, could cause differential dropout.
DHA-P and AL6 appear to have similar adverse effect profiles (moderate quality evidence).
Overall the two drugs, zanamivir and oseltamivir, have similar benefit profiles but quite different adverse effect profiles.
Despite the equivalent efficacy, the platinum-paclitaxel and platinum-LPD doublets generate extremely different adverse effect profiles.
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Currently, the recommended treatment for influenza is with the neuraminidase inhibitors (oseltamivir, zanamivir), which have a much safer adverse effect profile, and their effectiveness has been shown to be cost-effective (5 ).
In this comparative trial, although both treatments were effective, IV-MO had a shorter onset of analgesia in comparison with OTFC, while producing similar adverse effect profile, demonstrating safety and effectiveness.
This study shows that using carbetocin as a routine uterotonic drug administered as part of the active management of the third stage in uncomplicated labour and delivery is as effective as syntometrine but with a better adverse effect profile.
The adverse effect profile of an antimicrobial agent can contribute significantly to its overall direct costs and indirect costs.
Patients with OCD receiving SRIs who continue to have clinically significant symptoms should be offered EX/RP before antipsychotics given its superior efficacy and less negative adverse effect profile.clinicaltrials.gov Identifier: NCT00389493.
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