The phrase "adverse dependence" is correct and usable in written English.
It can be used in contexts discussing negative reliance or harmful relationships between variables, entities, or conditions.
Example: "The study revealed a significant adverse dependence between economic stability and unemployment rates."
Alternatives: "negative reliance" or "harmful dependence".
Drug dependence and adverse childhood experiences (ACE) are commonly reflected by dysregulation of the hypothalamic-pituitary-adrenal axis (HPA).
"The size of the sleeping pill market can only go up because of the economy and stress". But sleep medications are not without risk: next-day drowsiness is the most common among a list of adverse reactions that include dependence and memory loss.
Others viewed the potential for dependence or adverse effects as less of a problem: "GPs stated that dependence was not really a problem for first-time users.
However, benzodiazepine receptor agonists is limited by concerns regarding long-term efficacy and the potential for abuse, dependence, and adverse effects [ 12].
Early and frequent alcohol use is associated with adverse trajectories leading to dependence in adulthood (Pitkanen et al., 2005; Hingson et al., 2006) as well as several adverse outcomes during adolescence (Fergusson and Horwood, 2000; Maughan et al., 2004).
30– 33 In clinical practice, treatment with opiates is conditioned by ethical, cultural, and legal considerations, because it can produce tolerance, adverse reactions, and physical dependence, leading to abstinence syndrome.
It is highly likely that the complex interactions of opioids and/or active compounds in bhang (Δ9-tetrahydrocannabinol), cigarettes (nicotine), rohypnol (benzodiazepines), alcohol, khat (cathinone), and anti-retroviral drugs promote the occurrence of drug dependence and adverse events.
This is in accordance with Hall and Lucke who noted that MPH is under "legal control because of the high rates of dependence and adverse effects experienced by regular users" [ 32].
Morphine is by far the most commonly used opioid, although its long-term use in chronic pain conditions is limited by a relevant spectrum of adverse effects, including constipation, dependence and tolerance (Anderson and Palmer, 2006; Oderda et al., 2007; Sadhasivam and Chidambaran, 2012).
