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We included the possibility of subsequent treatment before the advent of sequelae for syphilis (but not for gonorrhea and chlamydia) because the time span from infection to sequelae can be substantially longer for syphilis than for gonorrhea and chlamydia [ 5, 23].
This cost includes the possibility of neurosyphilis and cardiovascular syphilis in untreated syphilis cases, and allows for the possibility that treatment of syphilis would have occurred subsequently (either by the infected person seeking treatment or receiving treatment inadvertently through administration of antibiotics for an unrelated health condition), before the advent of sequelae [ 5].
The average treatment and sequelae cost per case of syphilis we applied ($572) was the same value we applied above for the sequelae cost averted per case of syphilis treated, because when calculating the sequelae cost of syphilis averted by treatment we allowed for the possibility of subsequent treatment for syphilis before the advent of sequelae.
Similar(57)
The system captures combinations of sequelae.
The risk for extragastrointestinal sequelae was higher than that of intragastrointestinal sequelae, and the time of onset for the 2 categories of sequelae differed.
The advent of antibiotics and appropriate surgical treatment has decreased the risk of serious sequelae secondary to pyogenic flexor tenosynovitis.
The advent of computers broke her heart.
Illustrated description of the advent of handwriting.
The advent of e-mail is one.
The advent of television?
What changed was "the advent of Roy".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com