With the advent of new methodologies for the study of big data, the advantage of cellular-application based methodologies is clear.
With the advent of new methodologies in the field of bioinformatics, more and more online Web applications emerged, capable of handling large-scale data, having as a major goal to retrieve, handle, combine or compute data regarding every single gene, enlightening the understanding of its role from different perspectives.
However, the significant progress made in the incorporation of unnatural amino acids into proteins together with the continuous advent of novel methodologies for their modification (e.g. metal-mediated strategies) has opened up new opportunities to explore and exploit bioorthogonal transformations using these reactive handles.
With the advent of high throughput methodologies that can capture thousands of data points, and powerful computational approaches, the reality of studying cellular processes at a systems level is upon us.
With the advent of functional postgenomic methodologies, i.e. transcriptomics, proteomics, and metabolomics, we are now able to listen to the 'tunes' played by microbial orchestras.
The advent of RNA-Seq methodology has allowed for the global profiling of small RNAs from archaeal model organisms and has revealed a plethora of experimentally verified C/D box sRNA sequences [ 15, 16, 18].
The past few years has witnessed the advent of several promising strategic methodologies for the aforementioned needs, which are due primarily to the important advances in nanofabrication technology.
One of the main steps in the rapid acceleration of water reuse is the advent of advanced membrane treatment methodologies, and their cost reductions are classified into four categories; membrane technologies include microfiltration (MF).
On the other hand, rare are the examples of automated procedures which would make it possible for this type of analysis to be carried out on a large scale, especially with the advent of high throughput genotyping methodologies now available.
Within the past 6 years, the advent of high-throughput sequencing methodologies has provided researchers and clinicians with an extremely powerful tool for querying large amounts of the genetic landscape within not only single individuals but also cohorts of many individuals.
