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The inferred ERα regulatory network model has the following features and advantages: Distinct genomic and non-genomic mechanisms.
RAC1 mutations are observed in 4 % of all melanomas and 9 % of sun-exposed melanomas and may occur either independently or in conjunction with BRAF and NRAS mutations, suggesting growth advantages distinct from activation of the MAP kinase signaling pathway [ 49, 50].
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CEO of Professional Science Editing for Scientists @ prosciediting.com