Our current findings demonstrate that stimulation of TLR9 signaling with CpG ODN has beneficial effects on both plaque and tangle pathologies without toxicity in 3xTg-AD mice, suggesting that stimulation of innate immunity has the possible advantage of concurrently addressing both of these fundamental lesions that characterize AD.
By setting reasonable and flexible objectives and taking advantage of administrative tools while concurrently listening to the market, planning authorities can, to a certain extent, counteract unwanted development pressures.
In tradable services, where America continued to have a comparative advantage, both value-added and employment rose concurrently.
Deaf subjects demonstrated a clear advantage over hearing subjects, requiring less time to concurrently discriminate a central target and localize a peripheral target embedded within a field of distractors.
The advantage of miRNA approaches is based on its ability to concurrently target multiple effectors of pathways.
Compared to cooperative diversity schemes where all relays transmit their message to the destination concurrently, several recent results have demonstrated the performance and implementation advantages of one or a subset of relays assisting transmissions in a wireless network[10 21].
The advantage of using microRNA approaches is based on its ability to concurrently target multiple effectors of pathways involved in cell differentiation, proliferation and survival.
We also discuss the advantages and disadvantages of testing the psychometric properties of the primary outcome measures concurrently with the trial.
An appealing advantage of running multiple chains is that these processes can be conducted concurrently with minimal coordination among tasks, as in the case of parallel Monte Carlo simulation.
The cDNA-AFLP method has the advantage that all treatments, time points and genotypes under investigation can be concurrently compared [ 56, 57].
The major advantage that this approach provides is the capacity to introduce multiple genetic modifications concurrently.
