It might explain why during affinity maturation in the first round, similar advantageous sequences were selected in CDR-H1, while in CDR-L1 no consensus could be observed.
Mahoney and Rood (1998) discuss several factors that may support establishment at high elevations relative to the water's edge including capillary rise, lateral subsurface water movement, and advantageous sequences of precipitation events.
With a continuous fitness scale, apart from neutral and inviable sequences, we would have to keep track of slightly and strongly deleterious as well as advantageous sequences, and would consequently need a much more elaborate mathematical procedure to account for the contributions from these different fitness classes.
It may be advantageous to sequence more samples using WES, and gain statistical power, than to sequence more of the genome.
It may thus be advantageous to sequence from the 5′ direction if there is a need to maximise the number of detected microsatellite sequences when developing microsatellite markers for C. japonica.
Basically, they found the study of the body motions to improve the operations by elimination of unnecessary motions, simplifying the necessary, and then creating an advantageous motion sequence for obtaining a maximum efficiency (Niebel and Freivalds 2003).
Whereas it would be advantageous to sequence all available isolates within a lineage, this approach is still prohibitively expensive and requires SNP detection by whole genome comparisons.
The same conclusion was also reached for population genomics studies [ 28], which showed that it was more advantageous to sequence more individuals at low-coverage than fewer individuals at high-coverage, with an optimum obtained at approximately 1 x.
The proximity of the breakpoint to the testis-determining gene DMRT1 (Smith et al. 2009) and the duplication of testis-specific (perhaps male-advantageous) PAK3 sequences around the breakpoint hint at genomic changes that could alter male function.
Although abundant diversity is a challenge to assays that rely on scoring fixed positions, it is advantageous to direct sequencing approaches because sequencing efficiency for genotyping scales directly with genetic diversity.
