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A 4-subsituted benzoic acid moiety was identified as an advantageous replacement for the 3′3′-dimethylsuccinate moiety present in previously disclosed MIs that illuminates new aspects of the topography of the pharmacophore.
The residues used on the present research (coal fly ash and carbide lime) offer an advantageous replacement to natural soils or Portland cement due to the pozzolanic reactions arising from SiO2 and Al2O3 (from coal fly ash) and Ca++ (from carbide lime), which strengthen and stiffen the blends.
The ultimate takeaway is that a self-policed, non-political Bitcoin exchange offers an enormously advantageous replacement to the money system in use today.
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We show that 1,4-diethers displaying an adequate hydrophobic and constrained shape are advantageous benzyloxy replacements.
There is wide agreement that hormone treatment for a few years, until a woman gets past the hot flash stage, is advantageous, as is hormone replacement for a limited time for women who have had their ovaries removed before natural menopause.
Although advantageous aspects of volume replacement with so-called "modern" isooncotic tetrastarch solutions, in particular in reaching early hemodynamic stability are comprehensible [31, 32], data on focussed, adequately powered, prospective clinical trials proving their outcome-relevance are needed.
Their results suggested that HVHF and column replacement were advantageous in improving MAP and in prolonging animals' survival.
Although advantageous aspects of volume replacement with so-called "modern" isooncotic tetrastarch solutions, in particular in reaching early hemodynamic stability are comprehensible [ 31, 32], data on focussed, adequately powered, prospective clinical trials proving their outcome-relevance are needed.
An excess of non-synonymous substitutions over synonymous substitutions (dN > dS) might indicate positive selection, suggesting that the replacement might be advantageous, while negative selection results from the scarcity of non-synonymous substitutions (dN < dS), indicating that a particular mutation most likely is deleterious and is being removed from the gene pool.
Titanium (Ti) and its alloys are widely used in biomedical devices as bone tissue replacements due to their advantageous bulk mechanical properties and biocompatibility.
Whenever indel substitutions do not imply drastic changes affecting protein function, structural divergence may be a source of variation able to promote advantageous changes more efficiently than nucleotide replacements.
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