The introduction of docetaxel in first-line treatment of advanced NSCLC resulted advantageous in progression-free survival in a recent randomised phase III trial that compared immediate docetaxel with docetaxel upon evidence of progression in non-progressing patients after four cycles of induction therapy with gemcitabine plus carboplatin.
These effects of IL-22 seem to be advantageous to tumour progression, and indeed, recent studies has reported that IL-22 is associated with tumour progression and prognosis in human malignancies (Kobold et al, 2013; Wen et al, 2014).
Inflammation in cancer, particularly macrophage infiltration and MMP-9 release, generates a microenvironment advantageous to neoplastic progression [31], with recent evidence indicating that a PMN source of MMP-9 can also promote tumorigenesis [32].
Such phenotypes are advantageous for tumour progression and survival.
These findings can be explained by proposing that canonical Notch signalling may promote differentiation in the urothelium, like in many squamous epithelia, and its suppression may therefore be advantageous for tumour progression.
Although complete or partial loss of TGF- β signals is permissive for early stages of tumour development, active TGF- β signalling with selective loss of growth inhibitory response of TGF- β may be advantageous for the progression and metastasis of cancer.
aCGH can detect the events that have been selectively advantageous during the tumor progression as consistently gained or lost regions across a set of samples.
It is often desirable to observe how a disease progresses over time in individual patients, rather than graphing group averages; and since multiple outcomes are typically recorded on each patient, it would be advantageous to visualise disease progression on multiple variables simultaneously.
These effects of benidipine seem to make the drug more advantageous in terms of the progression of renal outcome and prevention of cardiovascular events in patients with hypertensive CKD.
A number of mothers did not identify the introduction of CF as advantageous, but rather a 'natural progression' in the baby's development, and just 'something that was going to happen.' Most of the mothers interviewed had commenced solid foods prior to the recommendation of six months, yet for those who did wait some key advantages were identified.
It is therefore clear that the zebrafish mycobacterial infection model is quickly becoming an attractive and advantageous alternative for analyzing granuloma and disease progression in vivo.
