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Genetic instability occurs secondarily to selectively advantageous driver mutations.
Genetic instability should accelerate carcinogenesis by increasing the rate of advantageous driver mutations; however, genetic instability can also potentially retard tumour growth by increasing the rate of deleterious mutation.
Within the model, cells could acquire selectively advantageous driver mutations, that increased the relative fitness of the cell by a factor of (1+ s d ), selectively disadvantageous housekeeper mutations that decreased fitness by a factor of (1− s h ) and selectively neutral passenger mutations (Fig. 1).
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Thermoacoustic heat engines (TAEs) are potentially advantageous drivers for thermoacoustic refrigerators (TARs).
Cutting down the ETA with features like this is particularly advantageous since Uber and the driver don't usually get paid during the pre-pickup drive.
The other value is the 'politeness factor' which reduces the overall calculated advantage and which simulates the care drivers take when changing lane (i.e., the model may say it is advantageous to change lane, but the driver may be too polite or hesitant to do so).
In at-risk younger drivers, BMI was more advantageous for reducing DWI and other dangerous traffic violations over a 5-year duration than an intervention similar to that provided in many contemporary remedial programs.
Considering the exclusive nature of the tested mutations, the acquisition of additional driver mutations may not be advantageous to these tumour cells for clonal selection.
It has been derived that the time period of the k-th mutation is given by (1) t k = k ln s u d 2 2 s ln N where s is the advantageous selection coefficient, u the rate of driver mutations, d the number of sensitively mutated genes, k the number of susceptible genes (potential drivers), and N is the size of cell population.
What can be seen as advantageous for the acceptance of the system is that drivers overestimate others compliance to CCC advice when the actual compliance rate is low (i.e. 10%%).
Kosher in Ancient Hebrew means be advantageous, proper, suitable, or succeed according to the Brown-Driver-Briggs Hebrew and English Lexicon.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com