The underlying mechanism for this intra-tumoral heterogeneity can be explained by the clonal evolution model, whereby growth advantageous mutations cause the expansion of cancer cell subclones.
New gene variants (i.e., alleles) are produced by random mutation, and over the course of many generations, natural selection may favor advantageous variants, causing them to become more common in the population.
However, since vedaprofen is known to be a preferential cyclo-oxygenase-2 inhibitor in dogs [ 18], it would be advantageous for causing less adverse effects than other conventional NSAIDs, allowing long-term treatment with low incidence of gastrointestinal and renal adverse effects or on increase in bleeding time [ 28].
We show through a simulation model that ISs are gradually eliminated from a population even if IS transpositions occasionally cause advantageous mutations.
With regard to Fe homeostasis, Mo17 contributed some advantageous alleles which caused in combination with the more advantageous genetic background of B73 a transgressive segregation in some IRILs.
13, 14 For the treatment of EBV-associated malignant diseases, induction of lytic infection is advantageous because it causes lysis of EBV-infected tumor cells.
However, this "ringing" effect could be advantageous as it causes the highest uptake to be in the periphery of the tumor, giving a clear indication of the tumor boundaries.
…upper Seine valley, forcing the Peace of Saint-Germain (August 1570), which was very advantageous to the Huguenot cause.
He said that even the perception that Britain was pro-Arab, whether correct or not, afforded the British added credibility that could be advantageous to Washington's cause.
But, as seen and explained from here, the war so far has also produced consequences that appear advantageous to the Croatian cause.
Although severely defeated at Moncontour (October 1569), he rallied an army in southern France and advanced as far as the upper Seine valley, forcing the Peace of Saint-Germain (August 1570), which was very advantageous to the Huguenot cause.
