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Although a superiority in the efficacy of the two PA has not been proved yet, cladribine is used more often as first-line agent than pentostatin because of its advantageous administration and safety profile.
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Moreover, the number of receptors available on the cell membrane is limited, so high specific activity (SA, expressed in MBq per nmol of peptide) of labelled peptides is advantageous for administration in small animals e.g. mice (~25 g) (Breeman et al. 2001; Breeman et al. 1995; de Jong et al. 1999).
Dosage forms with fixed dose combinations of drugs is a frequent and advantageous mode of administration, but their production involves a number of technological problems.
A completely human fusion protein may be advantageous for repeated administration, as host immune responses may be avoided.
Although the roots are used externally, the relative safety is obviously advantageous since systemic administration and or systemic absorption of the root extract from site of topical application (as employed in ethnomedicine) may pose no risk of acute toxicity.
The vesicle formation of β-SQDG-C18 is advantageous to i.v. administration in its chemico-structural character.
Oral triptans may, in case of severe nausea/vomiting, be combined with the antiemetic metoclopramide [16] or domperidone; in some cases, non-oral administration is advantageous (nasal spray, suppository or subcutaneous injection).
Therefore, in selected patients this type of administration seems advantageous.
The low concentrations of N-retinylamides found in the liver after conjugate administration are advantageous for minimizing potential toxic side effects associated with the drug.
Whether the perception of Mr. McCain as being at odds with the administration is politically advantageous for him is a matter of debate among his supporters, but many of his more conservative advisers do not think it is a bad thing.
Delivery of vardenafil (for improvement of erectile function) via the inhaled route of administration may be advantageous in that this avoids extensive first pass metabolism and may therefore increase the bioavailability (hence the reliability of absorption) and shorten the time of pharmacological onset of activity.
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