Exact(4)
If the environment changes to one in which the pathway confers an advantage, selection would then favour acquisition of the complete set of genes.
For example, many pathogens have evolved strategies to limit immune detection or to manipulate the immune response to their advantage; selection for these traits is generally purifying.
In our simulations, a weak proliferative advantage (selection model parameter = 0.0059, selection model with cell death value = 0.011) was sufficient to drive the clonal expansion and account for the mutant clusters seen in the 80-year-old male we studied.
If, instead, the extension provides a fitness advantage, selection can act upon both its amino acid sequence (to tune its function), as well as the nucleotide sequence of its mRNA (to increase or otherwise regulate its readthrough rate).
Similar(56)
In rare cases, a spontaneous mutation will confer a selective advantage (positive selection) or disadvantage (purifying selection).
From an evolutionary viewpoint, four explanations are possible [18], [20]: (i) mutation-selection balance, (ii) heterozygote advantage (balancing selection), (iii) negative frequency-dependent selection, and (iv) ancestral neutrality.
One possible explanation of these patterns is that new duplicate genes diverge and confer some specific selective advantage (positive selection).
Our data also suggests that defective TGF-β signaling would provide GC B cells with a survival advantage during selection.
Increased CD25/IL-2Rα levels of developing Mysm1−/− thymocytes correlated with upregulation of Foxp3+ protein levels and mRNA expression as detected by FACS analysis and qPCR, and may confer a survival advantage during selection.
In an interview, Mrs. O'Brien, who now heads a charter school trade group, said her work for the Pataki administration was coincidental to Advantage's selection as the operator of the school.
While each of the B.C.S. bowl games have regional tie-ins to accommodate the six conference champions, the Orange Bowl took advantage of selection rules to trump the Rose Bowl and pit Iowa (11-1) against U.S.C. (10-2).
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