Sentence examples for advantage of variants from inspiring English sources

And γ j = 2 N r e f s i is the scaled selection, in which s i is the relative selective advantage of variants in population i.

We tested this prediction by investigating the association between the selective advantage of variants in the 21 escape events studied and the functional CTL response to that epitope.

They show that the degree of HLA protection associated with different alleles is related to the selective advantage of variants in the bound epitopes.

One famous example is the selective advantage of variants in the lactase gene (LCT) which preserves the ability to digest lactose, the major sugar in milk, after weaning and throughout adult life [13].

The means by which these mechanisms are currently being exploited by recombinant antibody engineering, and a path toward a future in which designed vaccines take advantage of variant ADCC activity are also discussed.

We found between-individual variation in the selective advantage of escape variants even at the same epitope, consistent with variation in the strength of the CTL response against the same epitope in different people or with variation in the nature of compensatory mutations between escape events.

Interestingly, in our dataset the selective advantage of escape variants in Gag was indeed significantly lower than the selective advantage of escape variants in other proteins (Fig. 2).

It is unclear why the selective advantage of escape variants varies.

As a further test, we compared the selective advantage of escape variants in epitopes bound by alleles associated with significant differences in progression to AIDS.

A third of between-individual variation in HLA-associated disease risk was predicted by the selective advantage of escape variants: a doubling in the evolutionary selective advantage was associated with a decrease in the AIDS-free period of 1.2 yrs.

In this study we estimated the in vivo evolutionary selective advantage of viral variants that escape the CTL response and related these estimates to the degree of protection conferred by the targeting CTL response.