The discovery of subtle, yet real, sex differences in recombination rates illustrates the advantages of replicating mapping studies in two independent mapping populations.
Wodarz also developed an extension of his previous model to study advantages and disadvantages of replicating versus nonreplicating viruses for cancer therapy [ 32].
Thus, while vaccination with replication-restricted VACV recombinants is highly desirable for safety reasons, there might be an advantage in the use of replicating vectors eliciting prolonged immune responses.
For athletes especially, the immediate advantages of virtually replicating a moving body are obvious.
Phenotyping strategies based on CSSL populations present the advantage of a relatively small number of lines to evaluate, with the possibility of replicating evaluations over space and time.
When compared to traditional two-dimensional cell culture, spheroids have the advantage of better replicating the 3D extracellular microenvironment and its associated growth factors and signaling cascades.
The probe level QC was realized by taking advantage of technical replicates performed on one pair of twins with 4 replicates for each singleton (i.e. genome-wide DNA methylation repeatedly measured on 4 DNA samples from each twin).
The DIGE technique has the advantage of increasing replicate number whilst keeping the number of 2D gels required relatively low.
Firstly, the proposed approach could not model the within-group variation and thus cannot effectively take advantage of biological replicates.
The software takes advantage of available replicate variance data to derive more robust and informative differential expression and abundance statistics, whisker plot and PCA visualizations for omics data interpretation.
